SPESP1

Across TCGA patient cohorts, SPESP1 protein abundance is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SPESP1-associated genes across cancer lineages are RNU6-36P, TRAJ24, and TRAJ22. Each is linked with SPESP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPESP1-to-partner and partner-to-SPESP1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPESP1 versus RNU6-36P in BRCA, with a Pearson correlation of 0.82.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPESP1→partner) and Y-score (partner→SPESP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU6-36P →	+1.983	+0.560	<.001	.006	3	1
BRCA	TRAJ24 →	+1.463	+0.530	<.001	.003	3	1
BRCA	TRAJ22 →	+1.463	+0.530	<.001	.003	3	1
BRCA	MTA3P1 →	+0.146	+0.530	.001	.003	3	1
BRCA	TOR1BP1 →	+0.186	+0.530	<.001	.003	3	1
BRCA	RARRES2P4 →	+0.303	+0.530	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

SPESP1 vs RNU6-36P — BRCA

Explore this scatter interactively →