SPEN

Across TCGA patient cohorts, SPEN RNA expression is significantly associated with the protein abundance of many other proteins, with 14,377 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SPEN-associated proteins across cancer lineages are WDR5, WRNIP1, and SPEN_S727. Each is linked with SPEN in more than 5 cancer types. Because this analysis shows association rather than direction, both SPEN-to-partner and partner-to-SPEN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPEN versus WDR5 in GBM, with a Pearson correlation of 0.49.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SPEN→partner) and Y-score (partner→SPEN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	WDR5 →	+0.219	+0.430	<.001	<.001	3	6
PDAC	WRNIP1 →	+0.327	+0.516	<.001	<.001	3	6
PDAC	SPEN_S727 →	+0.602	+0.399	.001	<.001	3	6
GBM	GATAD2B →	+0.385	+0.576	<.001	<.001	3	6
LSCC	SF3B3 →	+0.238	+0.546	<.001	<.001	3	6
GBM	HCFC1 →	+0.244	+0.498	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,377 associations by consensus.

SPEN vs WDR5 — GBM

Explore this scatter interactively →