SPEN

Across TCGA pan-cancer cohorts, SPEN RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of SPEN’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where SPEN RNA is repressed in tumor relative to normal tissue. In most cancer types SPEN is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, HNSC, and STAD are the cancer types where SPEN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPEN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−1.262	<.001	8	view →
HNSC	All	All	+0.682	<.001	8	view →
STAD	All	II,III,IV	+0.810	.001	6	view →
THCA	All	II,III,IV	−0.633	.001	6	view →
LIHC	All	All	+0.496	<.001	6	view →
BRCA	Female	All	−0.335	<.001	4	view →
CHOL	All	All	+1.244	<.001	3	view →
UCEC	All	All	−0.574	.007	2	view →
BLCA	All	III,IV	+0.407	.010	2	view →
LUSC	Male	II,III,IV	+0.386	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

SPEN–KICH

Open the KICH breakdown →