SPEN

Across TCGA patient cohorts, SPEN protein abundance is significantly associated with the RNA expression of many other genes, with 14,844 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SPEN-associated genes across cancer lineages are NOL9, PPP1R8, and UBE4B. Each is linked with SPEN in more than 6 cancer types. Because this analysis shows association rather than direction, both SPEN-to-partner and partner-to-SPEN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPEN versus NOL9 in LUAD, with a Pearson correlation of 0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPEN→partner) and Y-score (partner→SPEN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NOL9 →	+0.476	+0.132	<.001	<.001	3	7
LSCC	PPP1R8 →	+0.421	+0.189	<.001	<.001	3	6
LUAD	UBE4B →	+0.604	+0.159	<.001	<.001	3	6
HNSC	PTCD3 →	+0.576	+0.157	<.001	<.001	3	6
GBM	ESPL1 →	+0.906	+0.205	<.001	<.001	3	6
UCEC	SHPRH →	+0.418	+0.117	.003	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,844 associations by consensus.

SPEN vs NOL9 — LUAD

Explore this scatter interactively →