SPEN

Across TCGA patient cohorts, SPEN protein abundance is significantly associated with the protein abundance of many other proteins, with 25,048 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SPEN-associated proteins across cancer lineages are SAP130, NIPBL, and ZC3H13. Each is linked with SPEN in more than 9 cancer types. Because this analysis shows association rather than direction, both SPEN-to-partner and partner-to-SPEN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPEN versus SAP130 in GBM, with a Pearson correlation of 0.83.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SPEN→partner) and Y-score (partner→SPEN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SAP130 →	+0.356	+0.291	<.001	<.001	3	10
LSCC	NIPBL →	+0.299	+0.174	<.001	<.001	3	9
GBM	ZC3H13 →	+0.319	+0.262	<.001	<.001	3	9
BRCA	ELOA →	+0.342	+0.215	<.001	<.001	3	9
GBM	KAT7 →	+0.416	+0.273	<.001	<.001	3	9
GBM	RBBP5 →	+0.380	+0.285	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 25,048 associations by consensus.

SPEN vs SAP130 — GBM

Explore this scatter interactively →