SPEN

Across TCGA cell cohorts, SPEN mutation is significantly associated with the RNA expression of many other genes, with 2,031 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPEN-associated genes across cancer lineages are GNL2, GPD1L, and PSMD9. Each is linked with SPEN in more than 3 cancer types. Because this analysis shows association rather than direction, both SPEN-to-partner and partner-to-SPEN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GNL2 grouped by SPEN-low versus SPEN-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPEN→partner) and Y-score (partner→SPEN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GNL2 →	+0.295	+1.628	.005	.002	3	4
LARGE_INTESTINE	GPD1L →	+0.582	+2.222	.002	.001	3	4
BLOOD_Leukemia	PSMD9 →	+0.477	+2.444	<.001	<.001	3	3
BLOOD_Leukemia	NLGN2 →	+1.040	+2.700	<.001	.002	3	3
BLOOD_Leukemia	KCNAB3 →	+0.841	+1.936	<.001	.004	3	3
BLOOD_Leukemia	GPR137C →	+0.455	+3.503	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,031 associations by consensus.

GNL2 by SPEN expression — LARGE_INTESTINE

Explore this box plot interactively →