SPEM1

Across TCGA patient cohorts, SPEM1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,511 significant associations in total. STAD shows the largest number of these associations.

The most reproducible SPEM1-associated GO terms across cancer lineages are DNA-templated DNA replication, Positive regulation of DNA metabolic process, and DNA conformation change. Each is linked with SPEM1 in more than 16 cancer types. Because this analysis shows association rather than direction, both SPEM1-to-partner and partner-to-SPEM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated DNA replication grouped by SPEM1-low versus SPEM1-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPEM1→partner) and Y-score (partner→SPEM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	DNA-templated DNA replication →	+0.073	+0.148	<.001	<.001	3	17
STAD	Positive regulation of DNA metabolic process →	+0.050	+0.034	<.001	<.001	3	16
ESCA	DNA conformation change →	+0.072	+0.133	<.001	<.001	3	16
ESCA	DNA unwinding involved in DNA replication →	+0.058	+0.087	<.001	<.001	3	16
STAD	Regulation of cell cycle G2/M phase transition →	+0.053	+0.039	<.001	<.001	3	16
TGCT	Gephyrin clustering involved in postsynaptic density assembly →	+0.107	+0.572	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,511 associations by consensus.

DNA-templated DNA replication by SPEM1 expression — ESCA

Explore this box plot interactively →