SPEM1

Across TCGA pan-cancer cohorts, SPEM1 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated SPEM1 data layer compared with 3 for mutation status.

The strongest signal is observed in kidney chromophobe (KICH), where higher SPEM1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SPEM1 expression acts as an unfavorable survival marker, although some lineages such as CESC and SCLC show a favorable association.

KICH, COAD, and LIHC are the cancer types where SPEM1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Tertile	II,III,IV	0.070	0.828	<.001	66	view →
COAD	OS	Tertile	IV	0.058	0.699	<.001	63	view →
LIHC	OS	Tertile	All	0.355	0.720	<.001	60	view →
CHOL	OS	Tertile	III,IV	0.024	0.772	.008	54	view →
UVM	DFS	Tertile	All	0.129	0.767	<.001	27	view →
DLBC	OS	Tertile	III,IV	0.175	0.874	.025	27	view →
SARC	DFS	Tertile	All	0.518	0.651	.005	20	view →
READ	OS	Tertile	IV	0.077	1.000	.014	18	view →
CESC	DFS	Median	All	0.799	0.698	.030	14	view →
MESO	OS	Quartile	II,III,IV	0.261	0.431	.009	12	view →
SCLC	OS	Quartile	II,III,IV	0.692	0.323	.027	6	view →
LUSC	OS	Median	III,IV	0.888	0.341	.017	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

SPEM1–KICH (OS)

Open the KICH breakdown →