SPEM1

Across TCGA patient cohorts, SPEM1 mutation is significantly associated with the RNA expression of many other genes, with 983 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SPEM1-associated genes across cancer lineages are RPS29P10, RNA5SP461, and HSPD1P12. Each is linked with SPEM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPEM1-to-partner and partner-to-SPEM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS29P10 grouped by SPEM1-low versus SPEM1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPEM1→partner) and Y-score (partner→SPEM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RPS29P10 →	+0.245	+2.695	<.001	.003	3	3
SKCM	RNA5SP461 →	+0.130	+5.495	<.001	<.001	3	2
UCEC	HSPD1P12 →	+0.180	+2.664	.001	.001	3	2
SKCM	SETP3 →	+0.245	+3.207	<.001	.009	3	2
SKCM	SNX6P1 →	+0.078	+2.777	.006	.005	3	2
STAD	MIR6752 →	+0.575	+6.400	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 983 associations by consensus.

RPS29P10 by SPEM1 expression — SKCM

Explore this box plot interactively →