SPEM1

Across TCGA patient cohorts, SPEM1 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPEM1-associated genes across cancer lineages are GATA3, JNK2, and Myosin-IIa. Each is linked with SPEM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPEM1-to-partner and partner-to-SPEM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GATA3 grouped by SPEM1-low versus SPEM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPEM1→partner) and Y-score (partner→SPEM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GATA3 →	+0.214	+2.183	.031	.035	3	2
UCEC	JNK2 →	+0.355	+3.321	<.001	.010	3	1
UCEC	Myosin-IIa →	+0.232	+2.177	.017	.035	3	1
UCEC	N-Ras →	-0.170	-3.308	.006	.010	3	1
UCEC	P-Cadherin →	-0.194	-2.999	.010	.035	3	1
UCEC	PRAS40_pT246 →	+0.200	+2.183	.026	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

GATA3 by SPEM1 expression — UCEC

Explore this box plot interactively →