SPEM1

Across TCGA cell cohorts, SPEM1 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SPEM1-associated genes across cancer lineages are ECE2, TBC1D21, and TMEM82. Each is linked with SPEM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPEM1-to-partner and partner-to-SPEM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ECE2 grouped by SPEM1-low versus SPEM1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPEM1→partner) and Y-score (partner→SPEM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ECE2 →	+0.353	+4.054	<.001	.004	3	1
LARGE_INTESTINE	TBC1D21 →	+0.012	+4.437	<.001	.004	3	1
SKIN	TMEM82 →	+0.026	+4.273	<.001	.006	3	1
SKIN	C16orf90 →	+0.025	+4.467	.001	.004	3	1
SKIN	CELA2B →	+0.049	+4.467	<.001	.004	3	1
SKIN	C16orf82 →	+0.014	+5.562	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

ECE2 by SPEM1 expression — LARGE_INTESTINE

Explore this box plot interactively →