SPEG

Across TCGA pan-cancer cohorts, SPEG Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SPEG data layer compared with 26 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher SPEG Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SPEG expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

ACC, UCEC, and LUAD are the cancer types where SPEG Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.256	0.809	<.001	36	view →
UCEC	OS	Median	II,III,IV	0.911	0.448	.010	26	view →
LUAD	OS	Median	II,III,IV	0.222	0.561	<.001	14	view →
LUSC	OS	Median	IV	0.001	0.673	.014	12	view →
SKCM	OS	Median	IV	0.218	0.666	.001	9	view →
ESCA	OS	Median	All	0.451	0.703	.006	6	view →
LIHC	OS	Median	II,III,IV	0.255	0.768	.018	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SPEG–ACC (OS)

Open the ACC breakdown →