SPEG

Across TCGA pan-cancer cohorts, SPEG RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SPEG’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where SPEG RNA is repressed in tumor relative to normal tissue. In most cancer types SPEG is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.

BLCA, COAD, and UCEC are the cancer types where SPEG tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPEG RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−4.287	<.001	8	view →
COAD	Male	II,III,IV	−1.797	<.001	8	view →
UCEC	All	III,IV	−3.651	<.001	6	view →
BRCA	All	III,IV	−1.118	<.001	6	view →
STAD	Female	All	−2.862	<.001	4	view →
READ	All	All	−2.225	.001	4	view →
KIRC	Male	All	−0.200	<.001	4	view →
CHOL	Female	All	+2.983	<.001	3	view →
KICH	All	All	−0.631	.001	3	view →
PRAD	All	All	−1.111	<.001	2	view →
PAAD	All	All	+0.762	.042	2	view →
LUSC	All	All	+0.399	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SPEG–BLCA

Open the BLCA breakdown →