SPEG

Across TCGA patient cohorts, SPEG mutation is significantly associated with the total protein of many other genes, with 84 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPEG-associated genes across cancer lineages are C-Raf, TFRC, and mTOR_pS2448. Each is linked with SPEG in more than 4 cancer types. Because this analysis shows association rather than direction, both SPEG-to-partner and partner-to-SPEG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by SPEG-low versus SPEG-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPEG→partner) and Y-score (partner→SPEG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	C-Raf →	+0.302	+2.115	<.001	.018	3	5
UCEC	TFRC →	+0.311	+1.584	.012	.007	3	4
COAD	mTOR_pS2448 →	-0.142	-3.152	.019	.017	3	4
COAD	c-Met_pY1235 →	+0.097	+1.700	.004	.040	3	4
UCEC	Shc_pY317 →	-0.077	-0.761	.031	.038	3	4
UCEC	Caspase-7-cleavedD198 →	+0.581	+1.754	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 84 associations by consensus.

C-Raf by SPEG expression — BLCA

Explore this box plot interactively →