SPEG

Across TCGA cell cohorts, SPEG RNA expression is significantly associated with the go_rna of many other GO terms, with 5,722 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SPEG-associated GO terms across cancer lineages are Regulation of intracellular protein transport, Negative regulation of syncytium formation by plasma membrane fusion, and Negative regulation of myoblast fusion. Each is linked with SPEG in more than 15 cancer types. Because this analysis shows association rather than direction, both SPEG-to-partner and partner-to-SPEG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of intracellular protein transport grouped by SPEG-low versus SPEG-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPEG→partner) and Y-score (partner→SPEG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of intracellular protein transport →	+0.087	+1.960	<.001	<.001	3	16
STOMACH	Negative regulation of syncytium formation by plasma membrane fusion →	+0.156	+2.375	<.001	.001	3	16
STOMACH	Negative regulation of myoblast fusion →	+0.159	+2.830	<.001	<.001	3	16
LUNG_NSCLC_LUSC	Cell division →	+0.084	+2.337	.002	.001	3	15
OESOPHAGUS	Regulation of syncytium formation by plasma membrane fusion →	+0.105	+1.790	<.001	<.001	3	15
BONE	Regulation of intracellular transport →	+0.067	+1.822	.005	.004	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,722 associations by consensus.

Regulation of intracellular protein transport by SPEG expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →