SPEG

Across TCGA cell cohorts, SPEG mutation is significantly associated with the RNA expression of many other genes, with 1,372 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPEG-associated genes across cancer lineages are PLB1, RGPD6, and SLCO1C1. Each is linked with SPEG in more than 3 cancer types. Because this analysis shows association rather than direction, both SPEG-to-partner and partner-to-SPEG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLB1 grouped by SPEG-low versus SPEG-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPEG→partner) and Y-score (partner→SPEG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PLB1 →	-0.734	-2.502	.001	.001	3	4
LARGE_INTESTINE	RGPD6 →	+0.644	+2.000	.002	.004	3	3
LARGE_INTESTINE	SLCO1C1 →	+0.199	+1.450	.008	.005	3	3
LARGE_INTESTINE	MTFMT →	+0.494	+1.700	<.001	.005	3	3
LARGE_INTESTINE	SCO1 →	+0.678	+2.043	<.001	<.001	3	3
LARGE_INTESTINE	GNG4 →	-1.725	-2.257	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,372 associations by consensus.

PLB1 by SPEG expression — LARGE_INTESTINE

Explore this box plot interactively →