SPECC1L

Across TCGA patient cohorts, SPECC1L RNA expression is significantly associated with the protein abundance of many other proteins, with 14,967 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SPECC1L-associated proteins across cancer lineages are ZNF326, MAPK1, and YWHAQ. Each is linked with SPECC1L in more than 5 cancer types. Because this analysis shows association rather than direction, both SPECC1L-to-partner and partner-to-SPECC1L results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPECC1L versus ZNF326 in GBM, with a Pearson correlation of 0.41.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SPECC1L→partner) and Y-score (partner→SPECC1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ZNF326 →	+0.333	+0.300	<.001	<.001	3	5
GBM	MAPK1 →	+0.362	+0.351	.002	.004	2	6
LSCC	YWHAQ →	+0.325	+0.455	<.001	<.001	3	4
GBM	VSIR →	-0.514	-0.276	<.001	.001	3	4
GBM	MTA1 →	+0.429	+0.299	<.001	.001	3	4
GBM	PATZ1 →	+0.517	+0.317	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,967 associations by consensus.

SPECC1L vs ZNF326 — GBM

Explore this scatter interactively →