SPECC1L

Across TCGA pan-cancer cohorts, SPECC1L RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of SPECC1L’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SPECC1L RNA is repressed in tumor relative to normal tissue. In most cancer types SPECC1L is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

COAD, THCA, and HNSC are the cancer types where SPECC1L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPECC1L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−0.985	<.001	11	view →
THCA	Male	III,IV	−0.879	<.001	10	view →
HNSC	All	IV	+0.524	<.001	10	view →
LIHC	Female	II,III,IV	+1.208	<.001	9	view →
LUAD	Male	All	−0.535	<.001	7	view →
CHOL	Male	All	+1.589	<.001	5	view →
READ	All	All	−0.779	.002	3	view →
UCEC	All	All	−0.478	.009	2	view →
KIRC	Female	All	+0.356	.013	2	view →
PRAD	All	All	+0.292	.002	2	view →
LUSC	All	All	−0.196	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

SPECC1L–COAD

Open the COAD breakdown →