SPECC1L

Across TCGA patient cohorts, SPECC1L mutation is significantly associated with the RNA expression of many other genes, with 4,488 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPECC1L-associated genes across cancer lineages are OR56A7P, RNA5SP412, and CNOT7P1. Each is linked with SPECC1L in more than 2 cancer types. Because this analysis shows association rather than direction, both SPECC1L-to-partner and partner-to-SPECC1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR56A7P grouped by SPECC1L-low versus SPECC1L-high in ESCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPECC1L→partner) and Y-score (partner→SPECC1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	OR56A7P →	+0.119	+4.237	<.001	.003	3	3
UCEC	RNA5SP412 →	+0.468	+1.908	<.001	<.001	3	3
BLCA	CNOT7P1 →	+0.078	+3.052	<.001	.001	3	3
UCEC	RNA5SP176 →	+0.203	+2.742	<.001	.008	3	3
UCEC	RNA5SP413 →	+0.913	+1.561	<.001	.002	3	3
UCEC	RNA5SP410 →	+0.523	+1.730	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,488 associations by consensus.

OR56A7P by SPECC1L expression — ESCA

Explore this box plot interactively →