SPECC1L

Across TCGA patient cohorts, SPECC1L mutation is significantly associated with the total protein of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPECC1L-associated genes across cancer lineages are ERK2, MEK1, and p21. Each is linked with SPECC1L in more than 2 cancer types. Because this analysis shows association rather than direction, both SPECC1L-to-partner and partner-to-SPECC1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by SPECC1L-low versus SPECC1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPECC1L→partner) and Y-score (partner→SPECC1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.223	+1.836	<.001	.001	3	3
UCEC	MEK1 →	+0.499	+2.115	<.001	<.001	3	2
UCEC	p21 →	+0.160	+1.584	.008	.005	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.373	-1.340	.008	.015	3	2
UCEC	p62 Lck ligand →	+0.311	+1.857	.002	.004	3	2
UCEC	P-Cadherin →	-0.171	-4.087	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

ERK2 by SPECC1L expression — UCEC

Explore this box plot interactively →