SPECC1L

Across TCGA cell cohorts, SPECC1L RNA expression is significantly associated with the go_rna of many other GO terms, with 4,999 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPECC1L-associated GO terms across cancer lineages are Negative regulation of chromosome condensation, Symbiont-mediated disruption of host cellular anatomical structure, and Symbiont-mediated disruption of host anatomical structure. Each is linked with SPECC1L in more than 17 cancer types. Because this analysis shows association rather than direction, both SPECC1L-to-partner and partner-to-SPECC1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of chromosome condensation grouped by SPECC1L-low versus SPECC1L-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPECC1L→partner) and Y-score (partner→SPECC1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Negative regulation of chromosome condensation →	+0.132	+1.116	<.001	<.001	3	18
URINARY_TRACT	Symbiont-mediated disruption of host cellular anatomical structure →	+0.156	+1.157	<.001	.001	3	17
URINARY_TRACT	Symbiont-mediated disruption of host anatomical structure →	+0.156	+1.157	<.001	.001	3	17
OVARY	DNA replication-dependent chromatin assembly →	+0.112	+0.726	<.001	<.001	3	17
OESOPHAGUS	Endosomal transport →	+0.087	+1.679	<.001	<.001	3	17
OESOPHAGUS	Regulation of protein-containing complex disassembly →	+0.055	+1.225	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,999 associations by consensus.

Negative regulation of chromosome condensation by SPECC1L expression — LARGE_INTESTINE

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