SPECC1L

Across TCGA cell cohorts, SPECC1L mutation is significantly associated with the drug of many other genes, with 31 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPECC1L-associated genes across cancer lineages are Veliparib, Mirin, and Niraparib. Each is linked with SPECC1L in more than 1 cancer types. Because this analysis shows association rather than direction, both SPECC1L-to-partner and partner-to-SPECC1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Veliparib grouped by SPECC1L-low versus SPECC1L-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPECC1L→partner) and Y-score (partner→SPECC1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Veliparib →	+0.288	+2.807	.032	.046	3	1
LARGE_INTESTINE	Mirin →	+0.382	+2.807	.025	.037	3	1
LARGE_INTESTINE	Niraparib →	+0.416	+2.700	.009	.030	3	1
LARGE_INTESTINE	N24798-49-A1 →	+0.234	+2.807	.045	.045	3	1
LARGE_INTESTINE	GSK2801 →	+0.396	+3.064	.005	.009	3	1
LARGE_INTESTINE	AGI-6780 →	+0.349	+3.061	.047	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Veliparib by SPECC1L expression — LARGE_INTESTINE

Explore this box plot interactively →