SPECC1L-ADORA2A

Across TCGA patient cohorts, SPECC1L-ADORA2A RNA expression is significantly associated with the go_rna of many other GO terms, with 7,061 significant associations in total. STAD shows the largest number of these associations.

The most reproducible SPECC1L-ADORA2A-associated GO terms across cancer lineages are Protein polyubiquitination, Microtubule organizing center organization, and Epigenetic regulation of gene expression. Each is linked with SPECC1L-ADORA2A in more than 29 cancer types. Because this analysis shows association rather than direction, both SPECC1L-ADORA2A-to-partner and partner-to-SPECC1L-ADORA2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein polyubiquitination grouped by SPECC1L-ADORA2A-low versus SPECC1L-ADORA2A-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPECC1L-ADORA2A→partner) and Y-score (partner→SPECC1L-ADORA2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Protein polyubiquitination →	+0.057	+0.029	<.001	<.001	3	30
ESCA	Microtubule organizing center organization →	+0.077	+0.043	<.001	<.001	3	30
ESCA	Epigenetic regulation of gene expression →	+0.071	+0.047	<.001	<.001	3	30
UCS	RISC complex assembly →	+0.071	+0.048	<.001	<.001	3	29
ESCA	Peptidyl-lysine modification →	+0.069	+0.048	<.001	<.001	3	29
ESCA	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay →	+0.093	+0.048	<.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,061 associations by consensus.

Protein polyubiquitination by SPECC1L-ADORA2A expression — ESCA

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