SPECC1L-ADORA2A

Across TCGA pan-cancer cohorts, SPECC1L-ADORA2A RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SPECC1L-ADORA2A data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher SPECC1L-ADORA2A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SPECC1L-ADORA2A expression acts as an unfavorable survival marker, although some lineages such as STAD and UCS show a favorable association.

ACC, STAD, and LUSC are the cancer types where SPECC1L-ADORA2A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.166	0.660	<.001	109	view →
STAD	OS	Tertile	All	0.775	0.611	.001	59	view →
LUSC	DFS	Quartile	III,IV	0.292	0.935	<.001	32	view →
KICH	OS	Tertile	All	0.821	0.965	.009	26	view →
UCS	DFS	Median	II,III,IV	0.572	0.194	.005	26	view →
KIRP	OS	Tertile	II,III,IV	0.304	0.647	.015	25	view →
LGG	OS	Tertile	All	0.960	0.830	.001	23	view →
COAD	OS	Tertile	All	0.668	0.869	.006	22	view →
LUAD	DFS	Quartile	II,III,IV	0.465	0.090	.003	18	view →
GBM	OS	Median	All	0.554	0.302	.003	15	view →
READ	DFS	Quartile	III,IV	0.187	0.841	<.001	15	view →
CESC	DFS	Tertile	II,III,IV	0.677	0.813	.017	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SPECC1L-ADORA2A–ACC (DFS)

Open the ACC breakdown →