SPECC1

Across TCGA cell cohorts, SPECC1 mutation is significantly associated with the RNA expression of many other genes, with 235 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPECC1-associated genes across cancer lineages are CSNKA2IP, POTEB3, and FAM47B. Each is linked with SPECC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPECC1-to-partner and partner-to-SPECC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CSNKA2IP grouped by SPECC1-low versus SPECC1-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPECC1→partner) and Y-score (partner→SPECC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CSNKA2IP →	+0.036	+4.906	<.001	.006	3	1
STOMACH	POTEB3 →	+0.036	+4.432	<.001	.003	3	1
OVARY	FAM47B →	+0.012	+5.196	<.001	.005	3	1
LUNG_NSCLC_LUAD	NXNL1 →	+0.024	+5.228	.004	.005	3	1
LUNG_NSCLC_LUAD	POM121L12 →	+0.030	+6.266	<.001	<.001	3	1
SKIN	SLC10A2 →	+0.005	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 235 associations by consensus.

CSNKA2IP by SPECC1 expression — OESOPHAGUS

Explore this box plot interactively →