SPDYE4

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, SPDYE4 mutation is significantly associated with the RNA expression of many other genes, with 1,464 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPDYE4-associated genes across cancer lineages are HMGN1P20, LINC02505, and MON1A. Each is linked with SPDYE4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPDYE4-to-partner and partner-to-SPDYE4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPDYE4→partner) and Y-score (partner→SPDYE4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
SKCMHMGN1P20 →+0.082+3.186<.001.00932
SKCMLINC02505 →+0.424+3.106<.001.00432
UCECMON1A →+0.408+2.736<.001<.00132
UCECTMUB1 →+0.437+3.721<.001<.00132
UCECNCAPH2 →+0.550+3.938<.001<.00132
UCECCREB3 →+0.334+1.912.005.00432
Each partner links to its Q-omics profile. Showing the 6 strongest of 1,464 associations by consensus.

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