Across TCGA pan-cancer cohorts, SPDYE4 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated SPDYE4 data layer compared with 3 for mutation status.
The strongest signal is observed in mesothelioma (MESO), where higher SPDYE4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SPDYE4 expression acts as an unfavorable survival marker, although some lineages such as PAAD and HNSC show a favorable association.
MESO, PAAD, and HNSC are the cancer types where SPDYE4 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.