Across TCGA patient cohorts, SPDYE4 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPDYE4-associated genes across cancer lineages are eIF4G, Gab2, and JNK_pT183_Y185. Each is linked with SPDYE4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPDYE4-to-partner and partner-to-SPDYE4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPDYE4→partner) and Y-score (partner→SPDYE4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.290	+2.999	.023	.035	3	1
UCEC	Gab2 →	+0.470	+2.584	.001	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.188	-2.584	.006	.010	3	1
UCEC	MEK1 →	+0.432	+2.700	.004	.006	3	1
UCEC	MSH2 →	-0.338	-2.433	<.001	.018	3	1
UCEC	mTOR_pS2448 →	-0.198	-3.571	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Exploration

SPDYE4 survival (RNA) · tumor vs normal (RNA) · all SPDYE4 data types