SPDYE10P

Across TCGA pan-cancer cohorts, SPDYE10P RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated SPDYE10P data layer.

The strongest signal is observed in cholangiocarcinoma (CHOL), where higher SPDYE10P RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SPDYE10P expression acts as an unfavorable survival marker, although some lineages such as ESCA and STAD show a favorable association.

CHOL, CESC, and READ are the cancer types where SPDYE10P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CHOL	OS	Tertile	III,IV	0.024	0.772	.008	36	view →
CESC	DFS	Tertile	II,III,IV	0.186	0.544	.033	36	view →
READ	DFS	Tertile	IV	0.027	0.636	<.001	18	view →
ESCA	OS	Tertile	III,IV	0.653	0.330	.005	15	view →
KIRC	DFS	Tertile	All	0.525	0.687	.026	11	view →
STAD	OS	Tertile	III,IV	0.572	0.269	.009	6	view →
BRCA	DFS	Median	III,IV	0.928	0.848	.021	6	view →
SARC	DFS	Tertile	All	0.184	0.356	.033	6	view →
THCA	DFS	Tertile	IV	0.453	0.765	.023	6	view →
LGG	DFS	Tertile	All	0.737	0.855	.026	4	view →
THYM	DFS	Tertile	II,III,IV	1.000	0.861	.042	3	view →
SKCM	DFS	Tertile	All	0.280	0.190	.035	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

SPDYE10P–CHOL (OS)

Open the CHOL breakdown →