SPDYE1

Across TCGA patient cohorts, SPDYE1 mutation is significantly associated with the RNA expression of many other genes, with 812 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPDYE1-associated genes across cancer lineages are ALDOA, PKN3, and MFSD12. Each is linked with SPDYE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPDYE1-to-partner and partner-to-SPDYE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ALDOA grouped by SPDYE1-low versus SPDYE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPDYE1→partner) and Y-score (partner→SPDYE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ALDOA →	+0.460	+3.459	.006	.005	3	2
UCEC	PKN3 →	+0.853	+2.595	<.001	<.001	3	2
UCEC	MFSD12 →	+0.411	+3.507	.008	.002	3	2
UCEC	MON1A →	+0.371	+3.470	.001	.002	3	2
UCEC	CIAO2B →	+0.352	+2.108	.009	.003	3	2
UCEC	DTYMK →	+0.498	+2.246	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 812 associations by consensus.

ALDOA by SPDYE1 expression — UCEC

Explore this box plot interactively →