SPDYE1

Across TCGA pan-cancer cohorts, SPDYE1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of SPDYE1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SPDYE1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SPDYE1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, BLCA, and CHOL are the cancer types where SPDYE1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPDYE1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.085	<.001	7	view →
BLCA	All	All	+0.238	.001	6	view →
CHOL	All	All	+0.335	<.001	5	view →
THCA	All	II,III,IV	−0.136	<.001	5	view →
KIRC	All	All	+0.074	.001	5	view →
STAD	Male	II,III,IV	+0.372	.031	4	view →
LIHC	Male	All	+0.074	<.001	4	view →
KIRP	All	IV	+0.157	.025	2	view →
LUSC	Male	All	+0.135	.014	2	view →
KICH	All	All	−0.111	.012	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

SPDYE1–HNSC

Open the HNSC breakdown →