SPDYE1

Across TCGA cell cohorts, SPDYE1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,305 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPDYE1-associated GO terms across cancer lineages are Positive regulation of DNA recombination, Protein targeting to vacuole, and Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I. Each is linked with SPDYE1 in more than 15 cancer types. Because this analysis shows association rather than direction, both SPDYE1-to-partner and partner-to-SPDYE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA recombination grouped by SPDYE1-low versus SPDYE1-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPDYE1→partner) and Y-score (partner→SPDYE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Positive regulation of DNA recombination →	+0.065	+0.175	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Protein targeting to vacuole →	+0.081	+0.213	<.001	<.001	3	16
BONE	Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.176	+0.243	<.001	<.001	3	16
BONE	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.150	+0.203	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Protein localization to vacuole →	+0.077	+0.211	<.001	<.001	3	16
SKIN	Cytosolic transport →	+0.090	+0.271	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,305 associations by consensus.

Positive regulation of DNA recombination by SPDYE1 expression — LARGE_INTESTINE

Explore this box plot interactively →