SPDYE1

Across TCGA cell cohorts, SPDYE1 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPDYE1-associated genes across cancer lineages are CNMD, TMSB4Y, and ASCL3. Each is linked with SPDYE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPDYE1-to-partner and partner-to-SPDYE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CNMD grouped by SPDYE1-low versus SPDYE1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPDYE1→partner) and Y-score (partner→SPDYE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CNMD →	+0.020	+4.145	.009	.001	3	1
LARGE_INTESTINE	TMSB4Y →	+1.254	+3.556	.001	.007	3	1
LARGE_INTESTINE	ASCL3 →	+0.198	+3.726	<.001	.004	3	1
LARGE_INTESTINE	GALP →	+0.013	+4.022	<.001	.006	3	1
LARGE_INTESTINE	LIPN →	+0.018	+3.345	<.001	.007	3	1
LARGE_INTESTINE	GSG1L2 →	+0.013	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

CNMD by SPDYE1 expression — LARGE_INTESTINE

Explore this box plot interactively →