SPDYA

Across TCGA patient cohorts, SPDYA mutation is significantly associated with the RNA expression of many other genes, with 999 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPDYA-associated genes across cancer lineages are RNU6-715P, OR5L2, and RNU6-1286P. Each is linked with SPDYA in more than 1 cancer types. Because this analysis shows association rather than direction, both SPDYA-to-partner and partner-to-SPDYA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-715P grouped by SPDYA-low versus SPDYA-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPDYA→partner) and Y-score (partner→SPDYA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-715P →	+0.263	+7.930	<.001	.008	3	1
LUAD	OR5L2 →	+0.034	+7.930	<.001	.008	3	1
LUAD	RNU6-1286P →	+0.438	+7.930	<.001	.008	3	1
LUAD	RN7SKP109 →	+0.094	+7.930	<.001	.008	3	1
LUAD	AARS1P1 →	+0.069	+7.930	<.001	.008	3	1
LUAD	MIR4695 →	+0.348	+7.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 999 associations by consensus.

RNU6-715P by SPDYA expression — LUAD

Explore this box plot interactively →