SPDYA

Across TCGA pan-cancer cohorts, SPDYA RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated SPDYA data layer compared with 3 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher SPDYA RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SPDYA expression acts as an unfavorable survival marker, although some lineages such as UCS and BLCA show a favorable association.

ACC, KIRC, and LIHC are the cancer types where SPDYA RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.403	0.754	<.001	125	view →
KIRC	DFS	Median	All	0.452	0.723	<.001	122	view →
LIHC	DFS	Median	All	0.373	0.491	<.001	90	view →
MESO	DFS	Tertile	All	0.259	0.476	.001	77	view →
UCS	DFS	Tertile	III,IV	0.697	0.257	<.001	66	view →
BLCA	OS	Quartile	II,III,IV	0.561	0.246	.008	44	view →
UVM	DFS	Tertile	III,IV	0.230	0.856	.001	35	view →
LUAD	OS	Tertile	II,III,IV	0.244	0.099	.002	27	view →
PRAD	DFS	Tertile	All	0.837	0.937	.002	20	view →
HNSC	DFS	Quartile	All	0.787	0.652	.004	19	view →
LGG	DFS	Tertile	All	0.640	0.801	<.001	18	view →
KICH	DFS	Quartile	III,IV	0.053	1.000	.017	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

SPDYA–ACC (DFS)

Open the ACC breakdown →