SPDYA

Across TCGA patient cohorts, SPDYA mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPDYA-associated genes across cancer lineages are JNK_pT183_Y185, Rad50, and S6_pS235_S236. Each is linked with SPDYA in more than 1 cancer types. Because this analysis shows association rather than direction, both SPDYA-to-partner and partner-to-SPDYA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by SPDYA-low versus SPDYA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPDYA→partner) and Y-score (partner→SPDYA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.151	-3.169	.030	.019	3	1
UCEC	Rad50 →	-0.210	-3.169	.036	.019	3	1
UCEC	S6_pS235_S236 →	+0.389	+1.807	.029	.027	3	1
UCEC	S6_pS240_S244 →	+0.441	+3.000	.008	.001	3	1
UCEC	ASNS →	+0.384	+2.321	.010	.006	3	1
UCEC	ATM →	-0.521	-1.807	.005	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

JNK_pT183_Y185 by SPDYA expression — UCEC

Explore this box plot interactively →