SPDL1

Across TCGA patient cohorts, SPDL1 protein abundance is significantly associated with the RNA expression of many other genes, with 5,901 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SPDL1-associated genes across cancer lineages are KIF15, GINS1, and OIP5. Each is linked with SPDL1 in more than 5 cancer types. Because this analysis shows association rather than direction, both SPDL1-to-partner and partner-to-SPDL1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPDL1 versus KIF15 in UCEC, with a Pearson correlation of 0.49.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPDL1→partner) and Y-score (partner→SPDL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KIF15 →	+1.581	+0.516	<.001	.002	3	6
LUAD	GINS1 →	+1.174	+0.428	<.001	<.001	3	5
OV	OIP5 →	+1.072	+0.883	.002	.003	3	5
UCEC	NEIL3 →	+1.351	+0.846	<.001	<.001	3	5
OV	TIMELESS →	+1.254	+0.969	<.001	<.001	3	5
UCEC	LMNB1 →	+1.429	+0.686	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,901 associations by consensus.

SPDL1 vs KIF15 — UCEC

Explore this scatter interactively →