SPDL1

Across TCGA patient cohorts, SPDL1 protein abundance is significantly associated with the protein abundance of many other proteins, with 11,614 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SPDL1-associated proteins across cancer lineages are PRC1, ECT2_T359, and SETDB1_S1066. Each is linked with SPDL1 in more than 5 cancer types. Because this analysis shows association rather than direction, both SPDL1-to-partner and partner-to-SPDL1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPDL1 versus PRC1 in LUAD, with a Pearson correlation of 0.46.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SPDL1→partner) and Y-score (partner→SPDL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PRC1 →	+0.808	+0.689	<.001	<.001	3	5
LUAD	ECT2_T359 →	+2.269	+0.715	<.001	<.001	3	5
LUAD	SETDB1_S1066 →	+1.280	+0.562	<.001	<.001	3	5
LUAD	SPC24 →	+0.612	+0.502	<.001	<.001	3	5
LUAD	COIL_T303 →	+1.364	+0.549	<.001	<.001	3	5
LUAD	DLGAP4_T915 →	+0.974	+0.454	<.001	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,614 associations by consensus.

SPDL1 vs PRC1 — LUAD

Explore this scatter interactively →