SPDEF

Across TCGA cell cohorts, SPDEF mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SPDEF-associated genes across cancer lineages are C14orf180, MMP27, and KRTAP10-6. Each is linked with SPDEF in more than 1 cancer types. Because this analysis shows association rather than direction, both SPDEF-to-partner and partner-to-SPDEF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C14orf180 grouped by SPDEF-low versus SPDEF-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPDEF→partner) and Y-score (partner→SPDEF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C14orf180 →	+0.042	+5.201	<.001	.006	3	2
LUNG_NSCLC_LUAD	MMP27 →	+0.018	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	KRTAP10-6 →	+0.068	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	CCL23 →	+0.037	+5.228	.001	.005	3	1
LUNG_NSCLC_LUAD	SCYGR8 →	+0.019	+5.662	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

C14orf180 by SPDEF expression — BLOOD_Leukemia

Explore this box plot interactively →