SPCS2

Across TCGA patient cohorts, SPCS2 mutation is significantly associated with the RNA expression of many other genes, with 511 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPCS2-associated genes across cancer lineages are ATF4P1, MIR4646, and OR1X1P. Each is linked with SPCS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPCS2-to-partner and partner-to-SPCS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATF4P1 grouped by SPCS2-low versus SPCS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPCS2→partner) and Y-score (partner→SPCS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATF4P1 →	+0.060	+2.717	<.001	.006	3	2
CESC	MIR4646 →	+0.526	+5.103	<.001	.008	3	2
LIHC	OR1X1P →	+0.035	+5.268	.002	.006	3	1
UCEC	SLC25A17 →	+0.481	+3.346	.004	.005	3	1
UCEC	PHF5A →	+0.601	+3.226	.002	.009	3	1
UCEC	VTI1B →	+0.556	+3.459	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 511 associations by consensus.

ATF4P1 by SPCS2 expression — UCEC

Explore this box plot interactively →