SPC25

Across TCGA pan-cancer cohorts, SPC25 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SPC25 data layer compared with 25 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher SPC25 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SPC25 expression acts as an unfavorable survival marker.

ACC, COAD, and LUAD are the cancer types where SPC25 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.188	0.820	<.001	12	view →
COAD	OS	Median	All	0.172	0.870	<.001	12	view →
LUAD	OS	Median	All	0.338	0.834	.004	12	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SPC25–ACC (OS)

Open the ACC breakdown →