SPC25

Across TCGA pan-cancer cohorts, SPC25 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of SPC25’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SPC25 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SPC25 is over-expressed in tumor.

HNSC, KIRC, and BLCA are the cancer types where SPC25 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPC25 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+1.863	<.001	12	view →
KIRC	Male	IV	+1.359	<.001	12	view →
BLCA	Male	All	+2.621	<.001	11	view →
LUAD	Male	III,IV	+2.561	<.001	11	view →
KIRP	All	III,IV	+1.506	<.001	11	view →
COAD	Female	II,III,IV	+1.344	<.001	11	view →
LUSC	Female	II,III,IV	+3.027	<.001	9	view →
LIHC	Male	All	+1.947	<.001	9	view →
STAD	Female	All	+2.474	<.001	8	view →
UCEC	All	II,III,IV	+3.172	<.001	6	view →
BRCA	All	III,IV	+2.411	<.001	6	view →
CHOL	Male	All	+3.071	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

SPC25–HNSC

Open the HNSC breakdown →