SPC25

Across TCGA cell cohorts, SPC25 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,983 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPC25-associated GO terms across cancer lineages are Mitotic sister chromatid segregation, Spindle organization, and Mitotic spindle organization. Each is linked with SPC25 in more than 19 cancer types. Because this analysis shows association rather than direction, both SPC25-to-partner and partner-to-SPC25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitotic sister chromatid segregation grouped by SPC25-low versus SPC25-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPC25→partner) and Y-score (partner→SPC25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Mitotic sister chromatid segregation →	+0.135	+1.688	<.001	<.001	3	20
PANCREAS	Spindle organization →	+0.091	+1.641	<.001	<.001	3	20
OESOPHAGUS	Mitotic spindle organization →	+0.128	+1.146	<.001	.001	3	20
OESOPHAGUS	Chromosome segregation →	+0.128	+1.147	<.001	<.001	3	20
OESOPHAGUS	Regulation of mitotic nuclear division →	+0.187	+1.636	<.001	<.001	3	20
BLOOD_Myeloma	Immunoglobulin heavy chain V-D-J recombination →	+0.195	+1.372	<.001	.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,983 associations by consensus.

Mitotic sister chromatid segregation by SPC25 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →