SPC24

Across TCGA patient cohorts, SPC24 protein abundance is significantly associated with the protein abundance of many other proteins, with 28,252 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SPC24-associated proteins across cancer lineages are NCAPD2, RRM1, and SMC2. Each is linked with SPC24 in more than 9 cancer types. Because this analysis shows association rather than direction, both SPC24-to-partner and partner-to-SPC24 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPC24 versus NCAPD2 in GBM, with a Pearson correlation of 0.88.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SPC24→partner) and Y-score (partner→SPC24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NCAPD2 →	+0.813	+0.953	<.001	<.001	3	10
HNSC	RRM1 →	+0.514	+0.432	<.001	<.001	3	9
GBM	SMC2 →	+0.830	+0.986	<.001	<.001	3	9
GBM	SMC4 →	+0.797	+0.950	<.001	<.001	3	9
UCEC	TK1 →	+0.714	+0.732	<.001	<.001	3	9
GBM	NCAPH →	+0.843	+0.963	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 28,252 associations by consensus.

SPC24 vs NCAPD2 — GBM

Explore this scatter interactively →