Across TCGA cell cohorts, SPATS2L mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPATS2L-associated genes across cancer lineages are SPACA5B, ADIG, and GRM6. Each is linked with SPATS2L in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATS2L-to-partner and partner-to-SPATS2L results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATS2L→partner) and Y-score (partner→SPATS2L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SPACA5B →	+0.223	+5.643	<.001	.002	3	1
LUNG_SCLC	ADIG →	+0.061	+5.029	<.001	.006	3	1
LARGE_INTESTINE	GRM6 →	+0.069	+3.115	<.001	.004	3	1
LARGE_INTESTINE	FAM205C →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	KLHL14 →	+0.144	+3.817	.001	.002	3	1
LARGE_INTESTINE	FAM205A →	+0.022	+4.029	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

SPATS2L survival (RNA) · tumor vs normal (RNA) · all SPATS2L data types