SPATS1

Across TCGA patient cohorts, SPATS1 mutation is significantly associated with the RNA expression of many other genes, with 1,704 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATS1-associated genes across cancer lineages are RNU6-189P, TADA2A, and RN7SL783P. Each is linked with SPATS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATS1-to-partner and partner-to-SPATS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-189P grouped by SPATS1-low versus SPATS1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATS1→partner) and Y-score (partner→SPATS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-189P →	+0.243	+4.496	.003	.007	3	2
UCEC	TADA2A →	+0.451	+3.524	.003	.002	3	2
BLCA	RN7SL783P →	+0.143	+4.899	<.001	.005	3	2
BLCA	AQP7P3 →	+0.042	+4.588	<.001	.008	3	2
UCEC	CCDC43 →	+0.618	+3.491	.001	.002	3	2
UCEC	LRRC57 →	+0.470	+2.700	.003	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,704 associations by consensus.

RNU6-189P by SPATS1 expression — LUSC

Explore this box plot interactively →