SPATS1

Across TCGA pan-cancer cohorts, SPATS1 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated SPATS1 data layer compared with 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SPATS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SPATS1 expression acts as an unfavorable survival marker, although some lineages such as PAAD and BRCA show a favorable association.

HNSC, KICH, and DLBC are the cancer types where SPATS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	II,III,IV	0.552	0.711	.011	72	view →
KICH	DFS	Tertile	All	0.608	0.965	.002	66	view →
DLBC	DFS	Tertile	All	0.022	0.809	<.001	63	view →
READ	DFS	Tertile	III,IV	0.262	0.771	<.001	60	view →
PAAD	DFS	Tertile	All	0.480	0.225	.008	36	view →
UCS	DFS	Tertile	IV	0.230	0.767	.009	36	view →
BRCA	DFS	Tertile	IV	1.000	0.424	.012	30	view →
COAD	OS	Tertile	II,III,IV	0.155	0.651	.005	27	view →
KIRC	OS	Tertile	II,III,IV	0.588	0.708	.015	24	view →
LUSC	DFS	Median	All	0.847	0.624	.003	22	view →
CHOL	DFS	Tertile	All	0.037	0.486	.001	18	view →
SARC	OS	Tertile	All	0.677	0.872	.005	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

SPATS1–HNSC (DFS)

Open the HNSC breakdown →