SPATC1L

Across TCGA patient cohorts, SPATC1L mutation is significantly associated with the RNA expression of many other genes, with 86 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATC1L-associated genes across cancer lineages are MIR6504, VPS37A, and WHAMM. Each is linked with SPATC1L in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATC1L-to-partner and partner-to-SPATC1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6504 grouped by SPATC1L-low versus SPATC1L-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATC1L→partner) and Y-score (partner→SPATC1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR6504 →	+0.426	+4.101	.009	.001	3	2
UCEC	VPS37A →	+0.686	+3.332	.003	.005	3	1
UCEC	WHAMM →	+0.588	+3.354	<.001	.005	3	1
UCEC	AMFR →	+0.762	+3.364	<.001	.005	3	1
UCEC	UBAP1 →	+0.602	+3.218	.003	.009	3	1
UCEC	CENPN →	+0.971	+3.343	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 86 associations by consensus.

MIR6504 by SPATC1L expression — COAD

Explore this box plot interactively →