SPATA7

Across TCGA patient cohorts, SPATA7 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATA7-associated genes across cancer lineages are PCNA, Caspase-8, and IGFBP2. Each is linked with SPATA7 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA7-to-partner and partner-to-SPATA7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by SPATA7-low versus SPATA7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA7→partner) and Y-score (partner→SPATA7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.170	+1.807	.025	.025	3	2
UCEC	Caspase-8 →	-0.219	-2.000	.013	.003	3	2
UCEC	IGFBP2 →	-0.693	-1.807	.002	.025	3	1
UCEC	JNK2 →	+0.152	+1.662	.030	.011	3	1
UCEC	MEK1 →	+0.351	+2.000	.006	.003	3	1
UCEC	MSH2 →	-0.324	-3.781	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

PCNA by SPATA7 expression — UCEC

Explore this box plot interactively →