SPATA7

Across TCGA pan-cancer cohorts, SPATA7 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of SPATA7’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SPATA7 RNA is repressed in tumor relative to normal tissue. In most cancer types SPATA7 is over-expressed in tumor, although a few such as THCA and LUSC show the opposite, repressed pattern.

THCA, LUSC, and KICH are the cancer types where SPATA7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPATA7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	II,III,IV	−0.813	<.001	9	view →
LUSC	All	II,III,IV	−0.462	<.001	8	view →
KICH	Female	All	−0.870	<.001	7	view →
UCEC	All	All	−0.714	<.001	6	view →
LIHC	Female	All	+0.347	<.001	6	view →
BRCA	Female	All	−0.342	<.001	6	view →
LUAD	Female	III,IV	−0.468	.001	4	view →
COAD	Male	All	+0.397	.001	4	view →
CHOL	Male	All	+1.228	<.001	3	view →
ESCA	All	All	+0.446	.039	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

SPATA7–THCA

Open the THCA breakdown →